Issue 21, 2014
From the journal:

RSC Advances

Catalyst-free domino reaction in water/ethanol: an efficient, regio- and chemoselective one-pot multi-component synthesis of pyranopyrazole derivatives†

Majid Koohshari,a   Minoo Dabiri*a  and  Peyman Salehi*b  

* Corresponding authors

a Department of Chemistry, Shahid Beheshti University, G. C., P. O. Box 19396-4716, Tehran, Iran
E-mail: m-dabiri@sbu.ac.ir

b Department of Phytochemistry, Medicinal Plants and Drugs Research Institute, Shahid Beheshti University, G. C., Evin, Tehran 1983963113, Iran
E-mail: p-salehi@sbu.ac.ir

Abstract

The synthesis of pyrano[2,3-c]pyrazole derivatives has been described by regio- and chemoselective four-component reaction of a dialkyl 3-oxopentanedioate, an active carbonyl compound, hydrazine and malononitrile in water/ethanol as a green medium under catalyst-free condition.

Graphical abstract: Catalyst-free domino reaction in water/ethanol: an efficient, regio- and chemoselective one-pot multi-component synthesis of pyranopyrazole derivatives

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Article information

DOI
https://doi.org/10.1039/C3RA47639A
Article type
Communication
Submitted
14 Dec 2013
Accepted
31 Jan 2014
First published
03 Feb 2014

RSC Adv., 2014,4, 10669-10671

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Catalyst-free domino reaction in water/ethanol: an efficient, regio- and chemoselective one-pot multi-component synthesis of pyranopyrazole derivatives

M. Koohshari, M. Dabiri and P. Salehi, RSC Adv., 2014, 4, 10669 DOI: 10.1039/C3RA47639A

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