Issue 3, 2014
From the journal:

RSC Advances

Improved synthesis of tadalafil using dimethyl carbonate and ionic liquids†

Martyn J. Earle,*a   Marco Noè,*b   Alvise Perosab  and  Kenneth R. Seddona  

* Corresponding authors

a The QUILL Research Centre, School of Chemistry and Chemical Engineering, The Queen's University of Belfast, Belfast, UK
E-mail: quill@qub.ac.uk

b Dipartimento di Scienze Molecolari e Nanosistemi dell'Universita Ca' Foscari Venezia, Centre for Sustainable Technologies, Calle Larga S. Marta, 2137-30123 Venezia, Italy
E-mail: marco.noe@unive.it

Abstract

An improved synthesis of tadalafil, a drug for the treatment of male erectile dysfunction, involves the use of safer solvents and reagents as well as a reduced number of steps.

Graphical abstract: Improved synthesis of tadalafil using dimethyl carbonate and ionic liquids

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Article information

DOI
https://doi.org/10.1039/C3RA45982A
Article type
Paper
Submitted
21 Oct 2013
Accepted
14 Nov 2013
First published
15 Nov 2013

RSC Adv., 2014,4, 1204-1211

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Improved synthesis of tadalafil using dimethyl carbonate and ionic liquids

M. J. Earle, M. Noè, A. Perosa and K. R. Seddon, RSC Adv., 2014, 4, 1204 DOI: 10.1039/C3RA45982A

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