Domino condensation–heterocyclisation reactions: iodine catalyzed four component synthesis of 1,3-thiazine

Abstract

An efficient iodine-catalyzed approach to synthesise 1,3-thiazine has been developed, and this synthetic methodology is economical and uses cheap and readily available starting materials. This is the first example of constructing 1,3-thiazine via a sequential thia-Michael addition and cyclodehydration.