Issue 7, 2014

Organocatalytic stereoselective approach to the total synthesis of (−)-halosaline

Abstract

A practical and efficient organocatalytic approach to the synthesis of substituted piperidine alkaloids in high enantio- and diastereomeric excess was achieved using proline-catalyzed sequential α-aminoxylation/α-amination reaction and HWE olefination reaction of an aldehyde.

Graphical abstract: Organocatalytic stereoselective approach to the total synthesis of (−)-halosaline

Supplementary files

Article information

Article type
Paper
Submitted
28 Aug 2013
Accepted
19 Nov 2013
First published
22 Nov 2013

RSC Adv., 2014,4, 3238-3244

Organocatalytic stereoselective approach to the total synthesis of (−)-halosaline

V. Jha and P. Kumar, RSC Adv., 2014, 4, 3238 DOI: 10.1039/C3RA44700F

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