We here report on the furan oxidation methodology for interstrand cross-linking of RNA duplexes, which have a different structure and are more stiff, reactive and labile than their DNA counterparts. Through this mildly inducible approach, natural unmodified RNA can be selectively cross-linked in high yield. The method therefore has direct applications in the increasing number of RNA based technologies.
L. L. G. Carrette, E. Gyssels, J. Loncke and A. Madder, Org. Biomol. Chem., 2014, 12, 931 DOI: 10.1039/C3OB42374C
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