Issue 8, 2014
From the journal:

MedChemComm

Structure activity relationship study of mezzettiasides natural products and their four new disaccharide analogues for anticancer/antibacterial activity†

Sumit O. Bajaj,‡a   Pei Shi,‡a   Penny J. Beuning*a  and  George A. O'Doherty*a  

* Corresponding authors

a Department of Chemistry and Chemical Biology, Northeastern University, Boston, MA 02115, USA
E-mail: G.ODoherty@neu.edu

Abstract

Ten members of the mezzettiaside family of natural products were synthesized and evaluated for anticancer and antibacterial activity. Complete anticancer (H460) and antibacterial (B. subtilis) activities for the ten natural products and four new analogues were found. Comparison to the cleistrioside and cleistetroside classes of natural products were made.

Graphical abstract: Structure activity relationship study of mezzettiasides natural products and their four new disaccharide analogues for anticancer/antibacterial activity

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Article information

DOI
https://doi.org/10.1039/C4MD00095A
Article type
Concise Article
Submitted
04 Mar 2014
Accepted
20 Mar 2014
First published
21 Mar 2014

Med. Chem. Commun., 2014,5, 1138-1142

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Structure activity relationship study of mezzettiasides natural products and their four new disaccharide analogues for anticancer/antibacterial activity

S. O. Bajaj, P. Shi, P. J. Beuning and G. A. O'Doherty, Med. Chem. Commun., 2014, 5, 1138 DOI: 10.1039/C4MD00095A

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