A light-triggered transmembrane porin

J. Kahlstatt; P. Reiß; T. Halbritter; L.-O. Essen; U. Koert; A. Heckel

doi:10.1039/C8CC05221B

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A light-triggered transmembrane porin†

J. Kahlstatt,

^a P. Reiß,^b T. Halbritter,

^a L.-O. Essen,

^bc U. Koert

*^b and A. Heckel

*^a

Author affiliations

* Corresponding authors

^a Goethe University Frankfurt, Institute for Organic Chemistry and Chemical Biology, Max-von-Laue-Str. 9, 60438 Frankfurt am Main, Germany
E-mail: heckel@uni-frankfurt.de

^b Philipps-University Marburg, Department of Chemistry, Hans-Meerwein-Str. 4, 35032 Marburg, Germany

^c Philipps-University Marburg, LOEWE Center for Synthetic Microbiology, 35032 Marburg, Germany

Abstract

Porins are ideal model systems for channel engineering. OmpG is a robust, monomeric, transmembrane β-barrel without ion selectivity. Here, we present a photocaged diethylaminocoumarin (DEACM) hybrid of OmpG. Blockage of the pore by DEACM is confirmed by reduced conductivity. An optimal effect was obtained when two bulky butyl-substituted coumarin cages were attached on the inside of the pore. Irradiation at 385 nm removed the photocages, leading to a restoration of channel conductivity.

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Article information

DOI: https://doi.org/10.1039/C8CC05221B
Article type: Communication
Submitted: 29 Jun 2018
Accepted: 06 Aug 2018
First published: 06 Aug 2018

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Chem. Commun., 2018,54, 9623-9626

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A light-triggered transmembrane porin

J. Kahlstatt, P. Reiß, T. Halbritter, L.-O. Essen, U. Koert and A. Heckel, Chem. Commun., 2018, 54, 9623 DOI: 10.1039/C8CC05221B

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Chemical Communications

A light-triggered transmembrane porin†

Abstract

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A light-triggered transmembrane porin

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