Issue 89, 2014
From the journal:

Chemical Communications

Esterase-activated release of naproxen from supramolecular nanofibres†

Martin Conda-Sheridan,‡a   Sungsoo S. Lee,‡b   Adam T. Preslarc  and  Samuel I. Stupp*abcde  

* Corresponding authors

a Simpson Querrey Institute for BioNanotechnology, Northwestern University, Chicago, USA
E-mail: s-stupp@northwestern.edu
Fax: +1 312 503 1222
Tel: +1 312 503 0807

b Department of Materials Science and Engineering, Northwestern University, Evanston, USA

c Department of Chemistry, Northwestern University, Evanston, USA

d Department of Medicine, Northwestern University, Chicago, USA

e Department of Biomedical Engineering, Northwestern University, Evanston, USA

Abstract

Nanofibre forming peptide amphiphiles were conjugated to naproxen through an esterase-sensitive linker. The amount of naproxen released, in the presence of enzymes, was influenced by the linker conjugating the drug to the supramolecular assembly. In vitro studies showed the anti-inflammatory activity of the released drug was maintained.

Graphical abstract: Esterase-activated release of naproxen from supramolecular nanofibres

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Article information

DOI
https://doi.org/10.1039/C4CC06340F
Article type
Communication
Submitted
12 Aug 2014
Accepted
18 Sep 2014
First published
24 Sep 2014

Chem. Commun., 2014,50, 13757-13760

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Esterase-activated release of naproxen from supramolecular nanofibres

M. Conda-Sheridan, S. S. Lee, A. T. Preslar and S. I. Stupp, Chem. Commun., 2014, 50, 13757 DOI: 10.1039/C4CC06340F

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