Oxidative coupling of alkenes with amides using peroxides: selective amide C(sp3)–H versus C(sp2)–H functionalization

Abstract

A new oxidative coupling of unactivated terminal alkenes with amides using peroxides is described, in which mono- and difunctionalization of alkenes are selectively achieved. In this reaction with amides, the chemoselectivity toward the functionalization of the C(sp³)–H bonds adjacent to the nitrogen atom or the functionalization of the carbonyl C(sp²)–H bonds across alkenes relies on the reaction conditions.