Issue 89, 2014

Copper-mediated aromatic amination reaction and its application to the total synthesis of natural products

Abstract

Herein, we review copper-mediated aromatic amination reactions including the classical Ullmann coupling and the recently developed mild aryl amination with an effective ligand as well as the C–H amination reaction. Several applications of intramolecular aryl amination to the syntheses of natural products demonstrate the general applicability of the reaction.

Graphical abstract: Copper-mediated aromatic amination reaction and its application to the total synthesis of natural products

Article information

Article type
Feature Article
Submitted
21 May 2014
Accepted
03 Jul 2014
First published
03 Jul 2014

Chem. Commun., 2014,50, 13650-13663

Author version available

Copper-mediated aromatic amination reaction and its application to the total synthesis of natural products

K. Okano, H. Tokuyama and T. Fukuyama, Chem. Commun., 2014, 50, 13650 DOI: 10.1039/C4CC03895A

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