Rhodium/phospholane–phosphite catalysts give unusually high regioselectivity in the enantioselective hydroformylation of vinyl arenes†
Abstract
Using the phospholane–phosphite ligand, BOBPHOS, almost perfect regioselectivities and high enantioselectivities (up to 92% ee) are observed in Rh catalysed enantioselective hydroformylation of vinyl arenes. This can be achieved under solvent-free conditions.