Metal-free nitro-carbocyclization of activated alkenes: a direct approach to synthesize oxindoles by cascade C–N and C–C bond formation†
Abstract
A novel and direct metal-free nitro-carbocyclization of activated alkenes leading to valuable nitro-containing oxindoles via cascade C–N and C–C bond formation has been developed. The mechanistic study indicates that the initial NO and NO2 radical addition and the following C–H functionalization processes are involved in this transformation.