Issue 1, 2013
From the journal:

Chemical Science

Compact tridentate ligands for enhanced aqueous stability of quantum dots and in vivo imaging†

Edmond Gravel,a   Chloé Tanguy,a   Elsa Cassette,b   Thomas Pons,b   Fabien Knittel,a   Nicholas Bernards,c   Anikitos Garofalakis,c   Frédéric Ducongé,c   Benoît Dubertret*b  and  Eric Doris*a  

* Corresponding authors

a CEA, iBiTecS, Service de Chimie Bioorganique et de Marquage, 91191 Gif-sur-Yvette, France
E-mail: eric.doris@cea.fr
Fax: +33 169 08 79 91
Tel: +33 169 08 80 71

b Laboratoire de Physique et d'Etude des Matériaux, UMR8213 du CNRS, ESPCI, 10 rue Vauquelin, 75005 Paris, France
E-mail: benoit.dubertret@espci.fr
Tel: +33 140 79 45 92

c CEA, I2BM, Service Hospitalier Frédéric Joliot, INSERM U1023, Laboratoire d'Imagerie Moléculaire Expérimentale, Université Paris Sud, 4 place du général Leclerc, 91401 Orsay, France

Abstract

We describe here a simple and versatile route for the preparation of a tridentate ligand that not only provides stable interactions with colloidal semiconductor nanocrystals (quantum dots, QDs) but also makes them water soluble. The designed ligand incorporates a biocompatible solubilizing polyethylene glycol (PEG) chain connected to a tridentate thiol motif with improved affinity towards the QDs surface. Stability experiments revealed better resistance to various drastic conditions compared to classical dihydrolipoic-based ligands. The enhanced stability of the assembly also enabled in vivo imaging experiments using near infrared-emitting QDs.

Graphical abstract: Compact tridentate ligands for enhanced aqueous stability of quantum dots and in vivo imaging

About
Cited by
Related
Download options Please wait...

Supplementary files

Article information

DOI
https://doi.org/10.1039/C2SC21113K
Article type
Edge Article
Submitted
30 Jul 2012
Accepted
10 Oct 2012
First published
11 Oct 2012

Chem. Sci., 2013,4, 411-417

Permissions

Request permissions

Compact tridentate ligands for enhanced aqueous stability of quantum dots and in vivo imaging

E. Gravel, C. Tanguy, E. Cassette, T. Pons, F. Knittel, N. Bernards, A. Garofalakis, F. Ducongé, B. Dubertret and E. Doris, Chem. Sci., 2013, 4, 411 DOI: 10.1039/C2SC21113K

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements