Human serum albumin mutants complexed Mn(III) protoporphyrin IX as superoxide dismutase mimics

Ryunosuke Kato; Yuya Kobayashi; Motofusa Akiyama; Teruyuki Komatsu

doi:10.1039/C3DT51418H

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Human serum albumin mutants complexed Mn(iii) protoporphyrin IX as superoxide dismutase mimics†

Ryunosuke Kato,^a Yuya Kobayashi,^a Motofusa Akiyama^a and Teruyuki Komatsu*^a

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* Corresponding authors

^a Department of Applied Chemistry, Faculty of Science and Engineering, Chuo University, 1-13-27 Kasuga, Bunkyo-ku, Tokyo 112-8551, Japan
E-mail: komatsu@kc.chuo-u.ac.jp
Fax: (+)81-3-3817-1910
Tel: (+)81-3-3817-1910

Abstract

Genetically engineered human serum albumin (HSA) mutants complexed Mn(III) protoporphyrin IX (MnPP) in the haem pocket showed superoxide dismutase activity. Replacement of a proximal Tyr-161 by non-coordinating Leu caused a remarkable increase in enzyme activity.

This article is part of the themed collection: Coordination Programming: Science of Molecular Superstructures Towards Chemical Devices

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Article information

DOI: https://doi.org/10.1039/C3DT51418H
Article type: Communication
Submitted: 31 May 2013
Accepted: 28 Jun 2013
First published: 28 Jun 2013

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Dalton Trans., 2013,42, 15889-15892

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Human serum albumin mutants complexed Mn(III) protoporphyrin IX as superoxide dismutase mimics

R. Kato, Y. Kobayashi, M. Akiyama and T. Komatsu, Dalton Trans., 2013, 42, 15889 DOI: 10.1039/C3DT51418H

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Dalton Transactions

Human serum albumin mutants complexed Mn(iii) protoporphyrin IX as superoxide dismutase mimics†

Abstract

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Human serum albumin mutants complexed Mn(III) protoporphyrin IX as superoxide dismutase mimics

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