Issue 18, 2013
From the journal:

CrystEngComm

Microwave assisted synthesis of caffeine/maleic acid co-crystals: the role of the dielectric and physicochemical properties of the solvent†

Sudhir Pagire,a   Sachin Korde,a   Rohan Ambardekar,a   Shivprasad Deshmukh,a   Radha Charan Dash,a   Ravindra Dhumala  and  Anant Paradkar*a  

* Corresponding authors

a Centre for Pharmaceutical Engineering Science, University of Bradford, Richmond Road, Bradford, BD7 1DP, UK
E-mail: a.paradkar1@bradford.ac.uk

Abstract

In the present work microwave radiation has been used to prepare the 1 : 1 and 2 : 1 co-crystals of caffeine and maleic acid. We obtained 1 : 1 co-crystals in the presence of water and methanol and we also see Form II of the 1 : 1 co-crystal in methanol. Co-crystallisation under microwave irradiation is shown to be controlled by the saturation of solvent at the reacting interface between the co-crystal components as well as the solvent dielectric properties.

Graphical abstract: Microwave assisted synthesis of caffeine/maleic acid co-crystals: the role of the dielectric and physicochemical properties of the solvent

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Article information

DOI
https://doi.org/10.1039/C3CE40292D
Article type
Paper
Submitted
07 Dec 2012
Accepted
26 Feb 2013
First published
26 Feb 2013

CrystEngComm, 2013,15, 3705-3710

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Microwave assisted synthesis of caffeine/maleic acid co-crystals: the role of the dielectric and physicochemical properties of the solvent

S. Pagire, S. Korde, R. Ambardekar, S. Deshmukh, R. C. Dash, R. Dhumal and A. Paradkar, CrystEngComm, 2013, 15, 3705 DOI: 10.1039/C3CE40292D

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