Issue 30, 2013
From the journal:

Chemical Communications

A chemo-enzymatic approach to specifically click-modified RNA†

Claudine M. Dojahn,a   Marlen Hessea  and  Christoph Arenz*a  

* Corresponding authors

a Humboldt Universität zu Berlin, Institute for Chemistry, Brook-Taylor-Str. 2, 12489 Berlin, Germany
E-mail: christoph.arenz@chemie.hu-berlin.de
Fax: + 49 302093-6947

Abstract

The growing interest in single-molecule analysis of RNA calls for programmable enzymatic labeling strategies beyond the horizon of solid-phase synthesized RNAs. Herein we describe an easy and versatile chemo-enzymatic approach to label RNA at its termini or defined internal positions via click-chemistry.

Graphical abstract: A chemo-enzymatic approach to specifically click-modified RNA

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Article information

DOI
https://doi.org/10.1039/C3CC40594J
Article type
Communication
Submitted
23 Jan 2013
Accepted
13 Feb 2013
First published
13 Feb 2013

Chem. Commun., 2013,49, 3128-3130

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A chemo-enzymatic approach to specifically click-modified RNA

C. M. Dojahn, M. Hesse and C. Arenz, Chem. Commun., 2013, 49, 3128 DOI: 10.1039/C3CC40594J

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