Issue 31, 2013

Label-free biosensing with single-molecule force spectroscopy

Abstract

We demonstrate here a novel single-molecule, label-free bioanalytical system capable of sensing the presence of specific ssDNA oligomer sequences and proteins with high selectivity and sensitivity. An ssDNA concentration of 1 nM and a Lyz concentration of 0.65 nM could be detected.

Graphical abstract: Label-free biosensing with single-molecule force spectroscopy

Supplementary files

Article information

Article type
Communication
Submitted
21 Jan 2013
Accepted
01 Mar 2013
First published
01 Mar 2013

Chem. Commun., 2013,49, 3239-3241

Label-free biosensing with single-molecule force spectroscopy

G. Wei, S. Steckbeck, S. Köppen and L. Colombi Ciacchi, Chem. Commun., 2013, 49, 3239 DOI: 10.1039/C3CC40506K

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