Issue 34, 2013
From the journal:

Journal of Materials Chemistry B

Cancer phototherapy in living cells by multiphoton release of doxorubicin from gold nanospheres†

Valerio Voliani,*ab   Giovanni Signore,c   Orazio Vittorio,bde   Paolo Faraci,b   Stefano Luin,b   Julia Peréz-Prietoa  and  Fabio Beltramb  

* Corresponding authors

a Universidad de Valencia, Instituto de Ciencia Molecular, ICMol, Catedrático Jose Beltrán, 2, 46980 Paterna, Valencia, Spain
E-mail: v.voliani@sns.it

b NEST-Scuola Normale Superiore and Istituto Nanoscienze-CNR, Piazza San Silvestro 12, 56127 Pisa, Italy

c Center for Nanotechnology Innovation @NEST, Istituto Italiano di Tecnologia, Piazza San Silvestro 12, 56127 Pisa, Italy

d Children's Cancer Institute Australia, Lowy Cancer Research Centre, University of New South Wales, Randwick, New South Wales, Australia

e Australian Centre for Nanomedicine, University of New South Wales, Randwick, New South Wales, Australia

Abstract

Doxorubicin is a widely used but toxic cancer chemotherapeutic agent. In order to localize its therapeutic action and minimize side effects, it was covalently conjugated to peptide-encapsulated gold nanospheres by click-chemistry and then photo-released in a controlled fashion by a multiphoton process. Selective treatment of a chosen region in a 2D layer of U2Os cancer cells is shown by driving photorelease with 561 nm irradiation at μW power. These results show promising directions for the development of practical applications based on nanocarriers that can ensure drug delivery with high spatial and temporal control.

Graphical abstract: Cancer phototherapy in living cells by multiphoton release of doxorubicin from gold nanospheres

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Article information

DOI
https://doi.org/10.1039/C3TB20798F
Article type
Paper
Submitted
05 Jun 2013
Accepted
11 Jul 2013
First published
11 Jul 2013

J. Mater. Chem. B, 2013,1, 4225-4230

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Cancer phototherapy in living cells by multiphoton release of doxorubicin from gold nanospheres

V. Voliani, G. Signore, O. Vittorio, P. Faraci, S. Luin, J. Peréz-Prieto and F. Beltram, J. Mater. Chem. B, 2013, 1, 4225 DOI: 10.1039/C3TB20798F

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