Issue 4, 2013
From the journal:

Journal of Materials Chemistry B

A novel fluorescent probe for selective detection of thiols in acidic solutions and labeling of acidic organelles in live cells†

Qin-Hua Song,*a   Qing-Qing Wu,a   Chang-Hui Liu,a   Xiao-Jiao Dub  and  Qing-Xiang Guoa  

* Corresponding authors

a Department of Chemistry, Joint Laboratory of Green Synthetic Chemistry, University of Science and Technology of China, Hefei 230026, P. R. China

b School of Life Science, University of Science and Technology of China, Hefei 230027, P. R. China

Abstract

A novel fluorescent probe, quinoline α,β-unsaturated diacid (QMA), as compared to its ester QME, was constructed and can selectively detect thiols in acidic solutions (pH < 7) via a H-bond activated Michael addition. Furthermore, labeling of lysosomes and cell imaging were achieved by the detection of biothiols in different domains of live cells.

Graphical abstract: A novel fluorescent probe for selective detection of thiols in acidic solutions and labeling of acidic organelles in live cells

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Article information

DOI
https://doi.org/10.1039/C2TB00402J
Article type
Communication
Submitted
12 Nov 2012
Accepted
04 Dec 2012
First published
05 Dec 2012

J. Mater. Chem. B, 2013,1, 438-442

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A novel fluorescent probe for selective detection of thiols in acidic solutions and labeling of acidic organelles in live cells

Q. Song, Q. Wu, C. Liu, X. Du and Q. Guo, J. Mater. Chem. B, 2013, 1, 438 DOI: 10.1039/C2TB00402J

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