Issue 34, 2013
From the journal:

RSC Advances

N-chlorosuccinimide, an efficient peptidedisulfide bond-forming reagent in aqueous solution†

Tobias M. Postmaab  and  Fernando Albericio*abcd  

* Corresponding authors

a Institute for Research in Biomedicine, Baldiri Reixac 10, Barcelona, Spain
E-mail: fernando.albericio@irbbarcelona.org
Fax: +34 93 40 37126
Tel: +34 93 40 37088

b CIBER-BBN, Barcelona, Spain

c Department of Organic Chemistry, Martí i Franquès 1, Barcelona, Spain

d School of Chemistry University of KwaZulu Natal, Durban, South Africa

Abstract

A novel method has been developed for the efficient formation of peptide disulfide bonds under aqueous conditions using N-chlorosuccinimide. Complete disulfide bond formation is achieved in 15 min with solvent mixtures containing water and acetonitrile.

Graphical abstract: N-chlorosuccinimide, an efficient peptide disulfide bond-forming reagent in aqueous solution

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Article information

DOI
https://doi.org/10.1039/C3RA43149E
Article type
Communication
Submitted
04 May 2013
Accepted
02 Jul 2013
First published
03 Jul 2013

RSC Adv., 2013,3, 14277-14280

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N-chlorosuccinimide, an efficient peptide disulfide bond-forming reagent in aqueous solution

T. M. Postma and F. Albericio, RSC Adv., 2013, 3, 14277 DOI: 10.1039/C3RA43149E

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