Issue 29, 2013

Base and ligand free copper-catalyzed N-arylation of 2-amino-N-heterocycles with boronic acids in air

Abstract

A wide range of N-arylated 2-amino-N-heterocycles were synthesized by a copper-catalyzed boronic acid cross coupling reaction at ambient temperature in air. This ligand and base free methodology is general and could provide rapid access to a diverse array of potential bioactive heterocyclic compounds.

Graphical abstract: Base and ligand free copper-catalyzed N-arylation of 2-amino-N-heterocycles with boronic acids in air

Supplementary files

Article information

Article type
Communication
Submitted
11 Feb 2013
Accepted
15 May 2013
First published
16 May 2013

RSC Adv., 2013,3, 11472-11475

Base and ligand free copper-catalyzed N-arylation of 2-amino-N-heterocycles with boronic acids in air

D. N. Rao, Sk. Rasheed, S. Aravinda, R. A. Vishwakarma and P. Das, RSC Adv., 2013, 3, 11472 DOI: 10.1039/C3RA40735G

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