Issue 7, 2013
From the journal:

RSC Advances

Indion 860 catalyzed cascade reaction: a greener approach to functionalized cyclohexanones and their novel analogues†

T. Bhaskar Kumar,ab   G. Dhananjaya,a   Ch. Sumanth,a   S. Vaishaly,a   Gajanan Botre,a   M. Srinivasa Rao,a   K. B. Chandra Sekhar,b   K. Shiva Kumarc  and  Manojit Pal*c  

* Corresponding authors

a Custom Pharmaceutical Services, Dr Reddy's Laboratories Limited, Bollaram Road Miyapur, Hyderabad 500 049, India

b Department of Chemistry, Institute of Science and Technology, JNT University of Anantapur, Anantapur 515002, Andhra Pradesh, India

c Institute of Life Sciences, University of Hyderabad Campus, Gachibowli, Hyderabad, India
E-mail: manojitpal@rediffmail.com

Abstract

An Indion 860 mediated cascade reaction of β-ketoester or 1,3-diketone with alkyl/aryl/heteroaryl aldehydes afforded functionalized cyclohexanones in the open air. The catalyst can be recovered and recycled. Combining this methodology with other reactions in the same pot afforded diversity based novel molecules. Some of the synthesized compounds showed inhibition of PDE4 in vitro.

Graphical abstract: Indion 860 catalyzed cascade reaction: a greener approach to functionalized cyclohexanones and their novel analogues

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Article information

DOI
https://doi.org/10.1039/C2RA23039A
Article type
Communication
Submitted
05 Oct 2012
Accepted
18 Dec 2012
First published
20 Dec 2012

RSC Adv., 2013,3, 2207-2210

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Indion 860 catalyzed cascade reaction: a greener approach to functionalized cyclohexanones and their novel analogues

T. Bhaskar Kumar, G. Dhananjaya, Ch. Sumanth, S. Vaishaly, G. Botre, M. S. Rao, K. B. C. Sekhar, K. S. Kumar and M. Pal, RSC Adv., 2013, 3, 2207 DOI: 10.1039/C2RA23039A

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