Issue 30, 2013
From the journal:

Organic & Biomolecular Chemistry

Transition metal free hydrolysis/cyclization strategy in a single pot: synthesis of fused furo N-heterocycles of pharmacological interest†

Ali Nakhi,a   Md. Shafiqur Rahman,ab   Guru Pavan Kumar Seerapu,a   Rakesh Kumar Banote,ac   Kummari Lalith Kumar,a   Pushkar Kulkarni,ac   Devyani Haldar*a  and  Manojit Pal*a  

* Corresponding authors

a Dr. Reddy's Institute of Life Sciences, University of Hyderabad Campus, Gachibowli, Hyderabad 500 046, India
E-mail: manojitpal@rediffmail.com
Tel: +91 40 6657 1500

b Chemical Synthesis and Process Technologies, Department of Chemistry, University of Delhi, New Delhi 110 007, India

c Zephase Therapeutics (an incubated company at the DRILS), University of Hyderabad Campus, Gachibowli, Hyderabad 500046, India

Abstract

A transition metal free tandem two-step strategy has been developed involving hydrolysis of 2-chloro-3-alkynyl quinoxalines/pyrazines followed by in situ cyclization of the corresponding 2-hydroxy-3-alkynyl intermediates in a single pot leading to fused furo N-heterocycles as potential inhibitors of sirtuins. A representative compound showed promising pharmacological properties in vitro and in vivo.

Graphical abstract: Transition metal free hydrolysis/cyclization strategy in a single pot: synthesis of fused furo N-heterocycles of pharmacological interest

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Article information

DOI
https://doi.org/10.1039/C3OB41069B
Article type
Communication
Submitted
23 May 2013
Accepted
17 Jun 2013
First published
18 Jun 2013

Org. Biomol. Chem., 2013,11, 4930-4934

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Transition metal free hydrolysis/cyclization strategy in a single pot: synthesis of fused furo N-heterocycles of pharmacological interest

A. Nakhi, Md. S. Rahman, G. P. K. Seerapu, R. K. Banote, K. L. Kumar, P. Kulkarni, D. Haldar and M. Pal, Org. Biomol. Chem., 2013, 11, 4930 DOI: 10.1039/C3OB41069B

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