Issue 25, 2013
From the journal:

Organic & Biomolecular Chemistry

Synthesis of analogs of the radiation mitigator JP4-039 and visualization of BODIPY derivatives in mitochondria†

Marie-Céline Frantz,a   Erin M. Skoda,a   Joshua R. Sacher,a   Michael W. Epperly,b   Julie P. Goff,b   Joel S. Greenbergerb  and  Peter Wipf*ac  

* Corresponding authors

a Department of Chemistry, University of Pittsburgh, Pittsburgh, PA 15260, USA
E-mail: pwipf@pitt.edu

b Department of Radiation Oncology, University of Pittsburgh Cancer Institute, Pittsburgh, PA 15232, USA

c Department of Pharmaceutical Sciences, University of Pittsburgh, Pittsburgh, PA 15260, USA

Abstract

JP4-039 is a lead structure in a series of nitroxide conjugates that are capable of accumulating in mitochondria and scavenging reactive oxygen species (ROS). To explore structure–activity relationships (SAR), new analogs with variable nitroxide moieties were prepared. Furthermore, fluorophore-tagged analogs were synthesized and provided the opportunity for visualization in mitochondria. All analogs were tested for radioprotective and radiomitigative effects in 32Dcl3 cells.

Graphical abstract: Synthesis of analogs of the radiation mitigator JP4-039 and visualization of BODIPY derivatives in mitochondria

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Article information

DOI
https://doi.org/10.1039/C3OB40489G
Article type
Communication
Submitted
09 Mar 2013
Accepted
15 May 2013
First published
17 May 2013

Org. Biomol. Chem., 2013,11, 4147-4153

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Synthesis of analogs of the radiation mitigator JP4-039 and visualization of BODIPY derivatives in mitochondria

M. Frantz, E. M. Skoda, J. R. Sacher, M. W. Epperly, J. P. Goff, J. S. Greenberger and P. Wipf, Org. Biomol. Chem., 2013, 11, 4147 DOI: 10.1039/C3OB40489G

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