Stoichiometric C–H arylation of tricarbonyl(arene)chromium complexes bearing pyridine directing groups

Abstract

Differentially substituted Cr(CO)₃-complexed aryl pyridines have been shown to readily undergo stoichiometric palladation and subsequent arylation using boronic acid nucleophiles. The positioning of the aryl substituents has been shown to be key in governing substrate reactivity, whereby sterically congested compounds prevent the geometry required for cyclometallation.