Issue 25, 2013
From the journal:

CrystEngComm

Spontaneous assembly of DNA–amorphous calcium phosphate nanocomposite spheres for surface-mediated gene transfer†

Ayako Oyane,*a   Hiroko Araki,a   Yu Sogo,b   Atsuo Itob  and  Hideo Tsurushimaac  

* Corresponding authors

a Nanosystem Research Institute, National Institute of Advanced Industrial Science and Technology (AIST), Central 4, 1-1-1 Higashi, Tsukuba, Ibaraki 305-8562, Japan
E-mail: a-oyane@aist.go.jp
Fax: +81-29-861-3005
Tel: +81-29-861-4693

b Human Technology Research Institute, National Institute of Advanced Industrial Science and Technology (AIST), Central 6, 1-1-1 Higashi, Tsukuba, Ibaraki 305-8566, Japan

c Department of Neurosurgery, Faculty of Medicine, University of Tsukuba, 1-1-1 Tennoudai, Tsukuba, Ibaraki 305-8575, Japan

Abstract

Submicrospheres composed of amorphous calcium phosphate (ACP) and DNA spontaneously assembled on a substrate via homogeneous calcium phosphate (CaP) nucleation followed by deposition in a highly supersaturated labile CaP solution. The nanocomposite layer of sphere assembly showed higher gene transfer efficiency than a continuous film nanocomposite layer previously fabricated via heterogeneous nucleation in a metastable supersaturated solution.

Graphical abstract: Spontaneous assembly of DNA–amorphous calcium phosphate nanocomposite spheres for surface-mediated gene transfer

About
Cited by
Related
Download options Please wait...

Supplementary files

Article information

DOI
https://doi.org/10.1039/C3CE40264A
Article type
Communication
Submitted
08 Feb 2013
Accepted
17 Apr 2013
First published
17 Apr 2013

CrystEngComm, 2013,15, 4994-4997

Permissions

Request permissions

Spontaneous assembly of DNA–amorphous calcium phosphate nanocomposite spheres for surface-mediated gene transfer

A. Oyane, H. Araki, Y. Sogo, A. Ito and H. Tsurushima, CrystEngComm, 2013, 15, 4994 DOI: 10.1039/C3CE40264A

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements