Issue 76, 2013
From the journal:

Chemical Communications

Different thermodynamic signatures for DNA minor groove binding with changes in salt concentration and temperature†

Shuo Wang,a   Arvind Kumar,a   Karl Aston,b   Binh Nguyen,‡a   James K. Bashkin,b   David W. Boykina  and  W. David Wilson*a  

* Corresponding authors

a Department of Chemistry, Georgia State University, Atlanta, GA 30303, USA
E-mail: wdw@gsu.edu
Fax: +1 404-413-5505
Tel: +1 404-413-5503

b Department of Chemistry & Biochemistry, Center for Nanoscience, University of Missouri-St. Louis, St. Louis, MO 63121, USA

Abstract

The effects of salt concentration and temperature on the thermodynamics of DNA minor groove binding have quite different signatures: binding enthalpy is salt concentration independent but temperature dependent. Conversely, binding free energy is salt dependent but essentially temperature independent through enthalpy–entropy compensation.

Graphical abstract: Different thermodynamic signatures for DNA minor groove binding with changes in salt concentration and temperature

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Article information

DOI
https://doi.org/10.1039/C3CC44569K
Article type
Communication
Submitted
18 Jun 2013
Accepted
07 Aug 2013
First published
08 Aug 2013

Chem. Commun., 2013,49, 8543-8545

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Different thermodynamic signatures for DNA minor groove binding with changes in salt concentration and temperature

S. Wang, A. Kumar, K. Aston, B. Nguyen, J. K. Bashkin, D. W. Boykin and W. D. Wilson, Chem. Commun., 2013, 49, 8543 DOI: 10.1039/C3CC44569K

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