Issue 49, 2013
From the journal:

Chemical Communications

A ratiometric naphthalimide sensor for live cell imaging of copper(i)†

Cristina Satriano,a   Giuseppe Trusso Sfrazzetto,a   Maria Emanuela Amato,a   Francesco P. Ballistreri,a   Agata Copani,bc   Maria Laura Giuffrida,c   Giuseppe Grasso,a   Andrea Pappalardo,a   Enrico Rizzarelli,*a   Gaetano A. Tomaselli*a  and  Rosa Maria Toscanoa  

* Corresponding authors

a Department of Chemical Sciences, University of Catania, viale Andrea Doria, 6, 95125 Catania, Italy
E-mail: erizzarelli@unict.it, gtomaselli@unict.it
Fax: +39 095 337678
Tel: +39 095 7385070

b Department of Drug Sciences, University of Catania, Viale Andrea Doria, Catania 95125, Italy

c Institute of Biostructure and Bioimaging, National Research Council, Viale Andrea Doria, Catania 95125, Italy

Abstract

A new naphthalimide derivative bearing a tetrathia-azacrown for high affinity and selective binding to Cu+ was synthesised. Copper recognition properties in solution were evaluated using 1H NMR and fluorescence spectroscopy. Live cell imaging by confocal microscopy highlighted the capabilities of the new sensor for the two-wavelength detection of intracellular monovalent copper in neuronal cells.

Graphical abstract: A ratiometric naphthalimide sensor for live cell imaging of copper(i)

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Article information

DOI
https://doi.org/10.1039/C3CC42069H
Article type
Communication
Submitted
21 Mar 2013
Accepted
23 Apr 2013
First published
25 Apr 2013

Chem. Commun., 2013,49, 5565-5567

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A ratiometric naphthalimide sensor for live cell imaging of copper(I)

C. Satriano, G. T. Sfrazzetto, M. E. Amato, F. P. Ballistreri, A. Copani, M. L. Giuffrida, G. Grasso, A. Pappalardo, E. Rizzarelli, G. A. Tomaselli and R. M. Toscano, Chem. Commun., 2013, 49, 5565 DOI: 10.1039/C3CC42069H

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