Issue 22, 2013
From the journal:

Chemical Communications

Human serum albumin (HSA) nanoparticles stabilized with intermolecular disulfide bonds†

Wentan Wang,a   Yanbin Huang,*a   Shufang Zhao,a   Ting Shaoa  and  Yi Cheng*a  

* Corresponding authors

a Department of Chemical Engineering, Tsinghua University, Beijing 100084, P. R. China
E-mail: yanbin@tsinghua.edu.cn, yicheng@tsinghua.edu.cn
Fax: +86-10-62772051
Tel: +86-10-62797572, +86-10-62794468

Abstract

We have presented a self-cross-link strategy to fabricate HSA nanoparticles using a desolvation method. The nanoparticles were stabilized by intermolecular disulfide bonds while still dissolvable in reducing media. The fabrication process does not involve any toxic chemicals and hence the nanoparticles may be useful as a drug carrier.

Graphical abstract: Human serum albumin (HSA) nanoparticles stabilized with intermolecular disulfide bonds

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Article information

DOI
https://doi.org/10.1039/C3CC38397K
Article type
Communication
Submitted
22 Nov 2012
Accepted
29 Jan 2013
First published
30 Jan 2013

Chem. Commun., 2013,49, 2234-2236

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Human serum albumin (HSA) nanoparticles stabilized with intermolecular disulfide bonds

W. Wang, Y. Huang, S. Zhao, T. Shao and Y. Cheng, Chem. Commun., 2013, 49, 2234 DOI: 10.1039/C3CC38397K

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