Issue 23, 2013
From the journal:

Chemical Communications

Glucose-Neopentyl Glycol (GNG) amphiphiles for membrane protein study†

Pil Seok Chae,*a   Rohini R. Rana,b   Kamil Gotfryd,c   Søren G. F. Rasmussen,d   Andrew C. Kruse,d   Kyung Ho Cho,a   Stefano Capaldi,b   Emil Carlsson,b   Brian Kobilka,d   Claus J. Loland,c   Ulrik Gether,c   Surajit Banerjee,e   Bernadette Byrne,*b   John K. Lee*f  and  Samuel H. Gellman*g  

* Corresponding authors

a Department of Bionano Engineering, Hanyang University, Ansan, Korea
E-mail: pchae@hanyang.ac.kr

b Department of Life Sciences, Imperial College London, London, UK
E-mail: b.byrne@imperial.ac.uk

c Department of Neuroscience and Pharmacology, University of Copenhagen, DK-2200 Copenhagen, Denmark
E-mail: cllo@sund.ku.dk

d Molecular and Cellular Physiology, Stanford University, Stanford, CA 94305, USA
E-mail: kobilka@stanford.edu

e DNE-CAT, Cornell University, Argonne, IL, USA
E-mail: sbanerjee@anl.gov

f Department of Biochemistry, University of Minnesota, Minneapolis, MN 55455, USA
E-mail: jklee@umn.edu

g Department of Chemistry, University of Wisconsin-Madison, Madison, WI 53706, USA
E-mail: gellman@chem.wisc.edu

Abstract

The development of a new class of surfactants for membrane protein manipulation, “GNG amphiphiles”, is reported. These amphiphiles display promising behavior for membrane proteins, as demonstrated recently by the high resolution structure of a sodium-pumping pyrophosphatase reported by Kellosalo et al. (Science, 2012, 337, 473).

Graphical abstract: Glucose-Neopentyl Glycol (GNG) amphiphiles for membrane protein study

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DOI
https://doi.org/10.1039/C2CC36844G
Article type
Communication
Submitted
20 Sep 2012
Accepted
02 Nov 2012
First published
05 Nov 2012

Chem. Commun., 2013,49, 2287-2289

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Glucose-Neopentyl Glycol (GNG) amphiphiles for membrane protein study

P. S. Chae, R. R. Rana, K. Gotfryd, S. G. F. Rasmussen, A. C. Kruse, K. H. Cho, S. Capaldi, E. Carlsson, B. Kobilka, C. J. Loland, U. Gether, S. Banerjee, B. Byrne, J. K. Lee and S. H. Gellman, Chem. Commun., 2013, 49, 2287 DOI: 10.1039/C2CC36844G

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