Issue 38, 2012

Quick regulation of mRNA functions by a few seconds of photoirradiation

Abstract

3-Cyanovinylcarbazole nucleoside, which effectively photocrosslinks to the pyrimidine base in complementary RNA strands, was incorporated into antisense oligonucleotides, and we evaluated the photoreactivity and the sequence selectivity to mutated K-ras oligoRNAs, as well as the regulation of the function of K-ras mRNA. We demonstrated that the reverse transcription and the translation activity of K-ras mRNA were quickly suppressed by a few seconds of photoirradiation with the addition of the photoresponsive antisense ODN.

Graphical abstract: Quick regulation of mRNA functions by a few seconds of photoirradiation

Supplementary files

Article information

Article type
Paper
Submitted
09 May 2012
Accepted
07 Aug 2012
First published
08 Aug 2012

Org. Biomol. Chem., 2012,10, 7820-7825

Quick regulation of mRNA functions by a few seconds of photoirradiation

A. Shigeno, T. Sakamoto, Y. Yoshimura and K. Fujimoto, Org. Biomol. Chem., 2012, 10, 7820 DOI: 10.1039/C2OB25883H

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