Issue 34, 2012

Insights into the elementary steps in Negishi coupling through kinetic investigations

Abstract

The Negishi coupling has been widely applied in organic synthesis, while relevant mechanistic studies are relatively rare. To obtain an understanding of the fundamental steps in the Negishi coupling, oxidative addition, transmetalation and reductive elimination, the kinetic investigation has served as one of the most important strategies. In this review, insights into the elementary steps in the Negishi coupling through kinetic investigations are summarized.

Graphical abstract: Insights into the elementary steps in Negishi coupling through kinetic investigations

Article information

Article type
Perspective
Submitted
31 Mar 2012
Accepted
15 Jun 2012
First published
18 Jun 2012

Org. Biomol. Chem., 2012,10, 6817-6825

Insights into the elementary steps in Negishi coupling through kinetic investigations

L. Jin and A. Lei, Org. Biomol. Chem., 2012, 10, 6817 DOI: 10.1039/C2OB25650A

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