Issue 7, 2012
From the journal:

MedChemComm

Alkaloids from Rutaceae: activities of canthin-6-one alkaloids and synthetic analogues on glioblastoma stems cells†

Gerardo Cebrián-Torrejón,‡a   Suzana Assad Kahn,‡b   Maria Elena Ferreira,c   Cécile Thirant,b   Antonieta Rojas de Arias,d   Bruno Figadère,a   Alain Fournet,e   Hervé Chneiweissb  and  Erwan Poupon*a  

* Corresponding authors

a Laboratoire de Pharmacognosie associé au CNRS, UMR 8076 BioCIS, LabEx LERMIT, Faculté de Pharmacie, Université Paris-Sud, 5, rue J.-B. Clément, 92296 Châtenay-Malabry, France
E-mail: erwan.poupon@u-psud.fr
Fax: +33-1-46 83 53 99
Tel: +33-1-46 83 55 86

b Glial Plasticity Laboratory, U894 Inserm, Université Paris-Descartes, Paris, France

c Department of Tropical Medicine, Casilla de Correo 2511, Instituto de Investigaciones en Ciencias de la Salud Asunción, Universidad Nacional de Asunción, Asunción, Paraguay

d Centro para el Desarrollo de la Investigación Científica (CEDIC/FMB/Diaz Gill Medicina Laboratorial), Asunción, Paraguay

e Institut de Recherche pour le Développement (IRD) UMR 217, Laboratoire de Pharmacognosie, Faculté de Pharmacie, 5, rue J.-B. Clément, 92296 Châtenay-Malabry, France

Abstract

Interesting selectivities for cancer stem cells versus neuronal stem cells are demonstrated in vitro with analogues of canthin-6-one, an indolic alkaloid isolated from Zanthoxylum chiloperone var. angustifolium (Rutaceae). The implication of the PI3/AKT signalling pathway is also disclosed.

Graphical abstract: Alkaloids from Rutaceae: activities of canthin-6-one alkaloids and synthetic analogues on glioblastoma stems cells

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Article information

DOI
https://doi.org/10.1039/C2MD20047C
Article type
Concise Article
Submitted
16 Feb 2012
Accepted
18 May 2012
First published
12 Jun 2012

Med. Chem. Commun., 2012,3, 771-774

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Alkaloids from Rutaceae: activities of canthin-6-one alkaloids and synthetic analogues on glioblastoma stems cells

G. Cebrián-Torrejón, S. A. Kahn, M. E. Ferreira, C. Thirant, A. Rojas de Arias, B. Figadère, A. Fournet, H. Chneiweiss and E. Poupon, Med. Chem. Commun., 2012, 3, 771 DOI: 10.1039/C2MD20047C

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