Issue 85, 2012
From the journal:

Chemical Communications

Catalysis-based enantioselective total synthesis of myxothiazole Z, (14S)-melithiazole G and (14S)-cystothiazole F†

Aude Colon,a   Thomas J. Hoffman,ab   Julian Gebauer,a   Jyotirmayee Dash,a   James H. Rigby,b   Stellios Arseniyadis*a  and  Janine Cossy*a  

* Corresponding authors

a Laboratoire de Chimie Organique, ESPCI ParisTech, CNRS, 10 rue Vauquelin, 75231 Paris Cedex 05, France
E-mail: stellios.arseniyadis@espci.fr, janine.cossy@espci.fr
Fax: +33 (0)1 40 79 46 60
Tel: +33 (0)1 40 79 46 62

b Department of Chemistry, Wayne State University, Detroit, Michigan 48202-3489, USA

Abstract

A common strategy for the stereoselective and protecting group-free total synthesis of the myxobacterial antibiotics myxothiazole Z, (14S)-melithiazole G and (14S)-cystothiazole F is described featuring an asymmetric organocatalytic transfer hydrogenation, a palladium-catalyzed Stille coupling and a cross-metathesis as the key steps.

Graphical abstract: Catalysis-based enantioselective total synthesis of myxothiazole Z, (14S)-melithiazole G and (14S)-cystothiazole F

About
Cited by
Related
Download options Please wait...

Supplementary files

Article information

DOI
https://doi.org/10.1039/C2CC35721F
Article type
Communication
Submitted
07 Aug 2012
Accepted
05 Sep 2012
First published
06 Sep 2012

Chem. Commun., 2012,48, 10508-10510

Permissions

Request permissions

Catalysis-based enantioselective total synthesis of myxothiazole Z, (14S)-melithiazole G and (14S)-cystothiazole F

A. Colon, T. J. Hoffman, J. Gebauer, J. Dash, J. H. Rigby, S. Arseniyadis and J. Cossy, Chem. Commun., 2012, 48, 10508 DOI: 10.1039/C2CC35721F

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements