Issue 38, 2012
From the journal:

Chemical Communications

Diarylprolinol in an asymmetric aldol reaction of an α-alkyl-α-oxo aldehyde as an electrophile†‡

Yujiro Hayashi,*a   Yusuke Yasui,a   Masahiro Kojima,a   Tsuyoshi Kawamuraa  and  Hayato Ishikawa§a  

* Corresponding authors

a Department of Industrial Chemistry, Faculty of Engineering, Tokyo University of Science, Kagurazaka, Shinjuku-ku, Tokyo 162-8601, Japan
E-mail: hayashi@ci.kagu.tus.ac.jp
Fax: +81 (0)3-5261-4631
Tel: +81 (0)3-5228-8318

Abstract

The direct aldol reaction of an α-alkyl-α-oxo aldehyde was catalyzed by trifluoromethyl-substituted diarylprolinol 1 to afford a γ-oxo-β-hydroxy-α-substituted aldehyde in good yield with excellent anti-selectivity and excellent enantioselectivity.

Graphical abstract: Diarylprolinol in an asymmetric aldol reaction of an α-alkyl-α-oxo aldehyde as an electrophile

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Article information

DOI
https://doi.org/10.1039/C2CC31230A
Article type
Communication
Submitted
18 Feb 2012
Accepted
05 Mar 2012
First published
30 Mar 2012

Chem. Commun., 2012,48, 4570-4572

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Diarylprolinol in an asymmetric aldol reaction of an α-alkyl-α-oxo aldehyde as an electrophile

Y. Hayashi, Y. Yasui, M. Kojima, T. Kawamura and H. Ishikawa, Chem. Commun., 2012, 48, 4570 DOI: 10.1039/C2CC31230A

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