Issue 8, 2012
From the journal:

RSC Advances

RuCl2(PPh3)3-catalyzed chemoselective hydrogenation of β, δ-diketo acid derivatives at the β-carbonyls†

Wan-Fang Li,a   Xiao-Min Xie,a   Xiao-Ming Tao,a   Xin Ma,a   Wei-Zheng Fan,a   Xiao-Ming Lia  and  Zhao-Guo Zhang*ab  

* Corresponding authors

a School of Chemistry and Chemical Engineering, Shanghai Jiao Tong University, 800 Dongchuan Road, Shanghai, China

b Shanghai Institute of Organic Chemistry, 345 Lingling Road, Shanghai, China
E-mail: zhaoguo@sjtu.edu.cn

Abstract

Chemoselective reduction of the β-carbonyls in β, δ-diketo acid derivatives was achieved through RuCl2(PPh3)3 catalyzed homogeneous hydrogenation. Tetrahydrofuran (THF) played a key role in the chemoselectivity control. This atom-economical protocol provided β-hydroxy-δ-keto esters and amides as useful intermediates in good to excellent yields.

Graphical abstract: RuCl2(PPh3)3-catalyzed chemoselective hydrogenation of β, δ-diketo acid derivatives at the β-carbonyls

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Article information

DOI
https://doi.org/10.1039/C2RA20114C
Article type
Communication
Submitted
19 Jan 2012
Accepted
15 Feb 2012
First published
08 Mar 2012

RSC Adv., 2012,2, 3214-3216

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RuCl2(PPh3)3-catalyzed chemoselective hydrogenation of β, δ-diketo acid derivatives at the β-carbonyls

W. Li, X. Xie, X. Tao, X. Ma, W. Fan, X. Li and Z. Zhang, RSC Adv., 2012, 2, 3214 DOI: 10.1039/C2RA20114C

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