The photobiology of melanocytes modulates the impact of UVA on sunlight-induced melanoma†
Abstract
Ultraviolet radiation is responsible for melanoma. In this review, we address the role of the different UV spectra in melanoma. The data suggest that only UVB is capable of initiating melanoma, and that both UVA and UVB are involved in the progression of the disease. The etiology of sunlight-induced melanoma may be different for chronically-exposed tumors and for those located on body surfaces with considerably less exposure. Solar signature mutations are most likely associated with the progression of chronically-exposed tumors. The unique relationship between UVA and melanocytes, and the role of
- This article is part of the themed collection: Biology of UVA