Bicyclic core estrogens as full antagonists: synthesis, biological evaluation and structure–activity relationships of estrogen receptor ligands based on bridged oxabicyclic core arylsulfonamides†
Abstract
Compounds that block
* Corresponding authors
a
Laboratory of Combinatorial Biosynthesis and Drug Discovery (Wuhan University), Ministry of Education, Wuhan University School of Pharmaceutical Sciences, Wuhan, China
E-mail:
zhouhb@whu.edu.cn
Fax: +86-27-68759850
Tel: +86-27-68759586
b
Department of Cancer Biology, The Scripps Research Institute-Florida, 130 Scripps Way, Jupiter, FL 33458, USA
E-mail:
knettles@scripps.edu
Fax: +1-561-799-8805
Tel: +1-561-228-3209
c
Department of Chemistry, University of Illinois, 600 South Mathews Avenue, Urbana, IL 61801, USA
E-mail:
jkatzene@illinois.edu
Fax: +1-217-333-7325
Tel: +1-217-333-6310
Compounds that block
M. Zhu, C. Zhang, J. C. Nwachukwu, S. Srinivasan, V. Cavett, Y. Zheng, K. E. Carlson, C. Dong, J. A. Katzenellenbogen, K. W. Nettles and H. Zhou, Org. Biomol. Chem., 2012, 10, 8692 DOI: 10.1039/C2OB26531A
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