Issue 12, 2012
From the journal:

Nanoscale

Bio-functionalization of ligand-free upconverting lanthanide doped nanoparticles for bio-imaging and cell targeting†

Nicoleta Bogdan,a   Emma Martín Rodríguez,a   Francisco Sanz-Rodríguez,b   Ma Carmen Iglesias de la Cruz,c   Ángeles Juarranz,b   Daniel Jaque,d   José García Soléd  and  John A. Capobianco*a  

* Corresponding authors

a Department of Chemistry and Biochemistry and Centre for Research in NanoScience, Concordia University, 7141 Sherbrooke Street West, Montreal, QC H4B 1R6, Canada
E-mail: capo@vax2.concordia.ca

b Departamento de Biología, Facultad de Ciencias, Universidad Autónoma de Madrid, 28049 Madrid, Spain

c Departamento de Fisiología, Facultad de Medicina, Universidad Autónoma de Madrid, 28049 Madrid, Spain

d Departamento de Física de Materiales, C-IV, Universidad Autónoma de Madrid, C/Francisco Tomas y Valiente 7, 28049 Madrid, Spain

Abstract

We report on the functionalization of ligand-free NaGdF4:Er3+, Yb3+ upconverting nanoparticles with heparin and basic fibroblast growth factor (bFGF). These upconverting nanoparticles are used to obtain high-contrast images of HeLa cells. These images reveal that the heparin–bFGF functionalized nanoparticles show specific binding to the cell membrane.

Graphical abstract: Bio-functionalization of ligand-free upconverting lanthanide doped nanoparticles for bio-imaging and cell targeting

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Article information

DOI
https://doi.org/10.1039/C2NR30982C
Article type
Communication
Submitted
24 Apr 2012
Accepted
14 May 2012
First published
15 May 2012

Nanoscale, 2012,4, 3647-3650

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Bio-functionalization of ligand-free upconverting lanthanide doped nanoparticles for bio-imaging and cell targeting

N. Bogdan, E. M. Rodríguez, F. Sanz-Rodríguez, M. xmlns="http://www.rsc.org/schema/rscart38"> <. C. Iglesias de la Cruz, Á. Juarranz, D. Jaque, J. G. Solé and J. A. Capobianco, Nanoscale, 2012, 4, 3647 DOI: 10.1039/C2NR30982C

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