Issue 15, 2012
From the journal:

Nanoscale

CTAB-coated gold nanorods elicit allergic response through degranulation and cell death in human basophils†

Ka Lun Cheung,a   Huanjun Chen,b   Qiulan Chen,c   Jianfang Wang,b   Ho Pui Ho,c   Chun Kwok Wongd  and  Siu Kai Kong*a  

* Corresponding authors

a Programme of Biochemistry, School of Life Sciences, Faculty of Science, The Chinese University of Hong Kong (CUHK), Shatin, NT, Hong Kong
E-mail: kalun2004@cuhk.edu.hk, skkong@cuhk.edu.hk

b Department of Physics, Faculty of Science, CUHK, Shatin, NT, Hong Kong
E-mail: hjchen@phy.cuhk.edu.hk, jfwang@phy.cuhk.edu.hk

c Department of Electronic Engineering, Faculty of Engineering, CUHK, Shatin, NT, Hong Kong
E-mail: orchid720@gmail.com, hpho@ee.cuhk.edu.hk

d Department of Chemical Pathology, CUHK, Prince of Wales Hospital, Shatin, NT, Hong Kong
E-mail: ck-wong@cuhk.edu.hk

Abstract

The effect of CTAB (cetyltrimethylammonium bromide)- or PEG (polyethylene glycol)-coated gold-nanorods (Au-NRs) on the non-IgE mediated allergic response was studied. We found that the CTAB-Au-NRs released more allergic mediators such as histamine and β-hexosaminidase from human basophil KU812, a common model for studying allergy, after 20 min incubation. Also, the CTAB-Au-NRs induced more apoptosis than the PEG-Au-NRs in KU812 24 h after treatment. These short- and long-term effects were not solely due to the CTAB residues in the supernatant desorbed from the Au-NRs.

Graphical abstract: CTAB-coated gold nanorods elicit allergic response through degranulation and cell death in human basophils

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Article information

DOI
https://doi.org/10.1039/C2NR30435J
Article type
Communication
Submitted
24 Feb 2012
Accepted
21 May 2012
First published
25 May 2012

Nanoscale, 2012,4, 4447-4449

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CTAB-coated gold nanorods elicit allergic response through degranulation and cell death in human basophils

K. L. Cheung, H. Chen, Q. Chen, J. Wang, H. P. Ho, C. K. Wong and S. K. Kong, Nanoscale, 2012, 4, 4447 DOI: 10.1039/C2NR30435J

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