Issue 3, 2012
From the journal:

Natural Product Reports

Advances in Aspergillussecondary metabolite research in the post-genomic era

James F. Sanchez,a   Amber D. Somoza,b   Nancy P. Kellerc  and  Clay C. C. Wang*ab  

* Corresponding authors

a University of Southern California – Pharmacology and Pharmaceutical Sciences, Los Angeles, California, USA
E-mail: clayw@usc.edu
Fax: 001-323-442-1365
Tel: 001-323-442-1670

b University of Southern California – Chemistry, Los Angeles, California, USA

c University of Wisconsin, Madison – Medical Microbiology & Immunology and Bacteriology, Madison, Wisconsin, USA

Abstract

Covering: 2005 to 2011

This review studies the impact of whole genome sequencing on Aspergillus secondary metabolite research. There has been a proliferation of many new, intriguing discoveries since sequencing data became widely available. What is more, the genomes disclosed the surprising finding that there are many more secondary metabolite biosynthetic pathways than laboratory research had suggested. Activating these pathways has been met with some success, but many more dormant genes remain to be awakened.

Graphical abstract: Advances in Aspergillus secondary metabolite research in the post-genomic era

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Article information

DOI
https://doi.org/10.1039/C2NP00084A
Article type
Review Article
Submitted
25 Oct 2011
First published
06 Jan 2012

Nat. Prod. Rep., 2012,29, 351-371

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Advances in Aspergillus secondary metabolite research in the post-genomic era

J. F. Sanchez, A. D. Somoza, N. P. Keller and C. C. C. Wang, Nat. Prod. Rep., 2012, 29, 351 DOI: 10.1039/C2NP00084A

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