Issue 10, 2012
From the journal:

Molecular BioSystems

Leveraging kinase inhibitors to develop small molecule tools for imaging kinases by fluorescence microscopy†‡

Zijuan Zhang,a   Nicholas Kwiatkowski,b   Hong Zeng,a   Sang Min Lim,b   Nathanael S. Gray,b   Wei Zhanga  and  Priscilla L. Yang*c  

* Corresponding authors

a Department of Chemistry, University of Massachusetts Boston, 100 Morrissey Boulevard, Boston, Massachusetts 02125, USA
E-mail: wei2.zhang@umb.edu

b Department of Cancer Biology, Dana-Farber Cancer Institute and Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, 250 Longwood Avenue, Boston, Massachusetts 02115, USA
E-mail: nathanael_gray@dfci.harvard.edu

c Department of Microbiology and Immunobiology, Harvard Medical School, 200 Longwood Avenue, Boston, Massachusetts 02115, USA
E-mail: priscilla_yang@hms.harvard.edu
Fax: +1-617-432-5418
Tel: +1-617-432-5415

Abstract

As the usage of fluorescence microscopy as a tool to study biological systems continues to grow, so does the need for additional tools that permit the selective detection of proteins of interest. Existing selective and well-characterized kinase inhibitors may be exploited to develop novel small molecule probes useful in imaging kinases by fluorescence microscopy.

Graphical abstract: Leveraging kinase inhibitors to develop small molecule tools for imaging kinases by fluorescence microscopy

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Article information

DOI
https://doi.org/10.1039/C2MB25099C
Article type
Communication
Submitted
16 Mar 2012
Accepted
10 May 2012
First published
10 May 2012

Mol. BioSyst., 2012,8, 2523-2526

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Leveraging kinase inhibitors to develop small molecule tools for imaging kinases by fluorescence microscopy

Z. Zhang, N. Kwiatkowski, H. Zeng, S. M. Lim, N. S. Gray, W. Zhang and P. L. Yang, Mol. BioSyst., 2012, 8, 2523 DOI: 10.1039/C2MB25099C

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