Issue 11, 2012
From the journal:

Journal of Materials Chemistry

Porphyrin containing light-responsive capsules for controlled drug release†

Cao Li,a   Ze-Yong Li,a   Jing Zhang,a   Kang Wang,a   Yu-Hui Gong,a   Guo-Feng Luo,a   Ren-Xi Zhuoa  and  Xian-Zheng Zhang*a  

* Corresponding authors

a Key Laboratory of Biomedical Polymers of Ministry of Education & Department of Chemistry, Wuhan University, Wuhan 430072, P. R. China
E-mail: xz-zhang@whu.edu.cn
Fax: +86 27 6875 4509
Tel: +86 27 6875 5993

Abstract

Porphyrin containing capsules with light-response were fabricated via Layer-by-Layer (LbL) assembly of two biocompatible polymers, chitosan (CHI) and 5-(4-aminophenyl)-10,15,20-triphenyl-porphyrin (APP) graft polyaspartic acid (PASP-g-APP), on CaCO3 particles. FITC labeled dextran (FITC-Dex) was encapsulated in the core as a model drug. With CaCO3 particles removal by EDTA, hollow capsules loaded with FITC-Dex were obtained. The capsules could degrade and release FITC-Dex with light illumination due to the reactive oxygen species (ROS) produced by porphyrin. Confocal laser scanning microscopy (CLSM), transmission electron microscopy (TEM), and scanning electron microscopy (SEM) were used to characterize the capsules. The degradation behavior of the capsules was studied with CLSM and TEM.

Graphical abstract: Porphyrin containing light-responsive capsules for controlled drug release

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Article information

DOI
https://doi.org/10.1039/C2JM16702F
Article type
Communication
Submitted
20 Dec 2011
Accepted
24 Jan 2012
First published
07 Feb 2012

J. Mater. Chem., 2012,22, 4623-4626

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Porphyrin containing light-responsive capsules for controlled drug release

C. Li, Z. Li, J. Zhang, K. Wang, Y. Gong, G. Luo, R. Zhuo and X. Zhang, J. Mater. Chem., 2012, 22, 4623 DOI: 10.1039/C2JM16702F

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