Issue 11, 2012
From the journal:

Green Chemistry

One-pot double [3 + 2] cycloaddition for diastereoselective synthesis of tetracyclic pyrrolidine compounds†

Qing Lu,ab   Gonghua Song,b   Jerry P. Jasinski,c   Amanda C. Keeleyc  and  Wei Zhang*a  

* Corresponding authors

a Department of Chemistry, University of Massachusetts Boston, 100 Morrissey Boulevard, Boston, USA
E-mail: wei2.zhang@umb.edu

b Shanghai Key Laboratory of Chemical Biology, Institute of Pesticides and Pharmaceuticals, East China University of Science and Technology, Shanghai 200237, P.R. China

c Department of Chemistry, Keene State College, 220 Main Street, Keene, USA

Abstract

A multicomponent double [3 + 2] cycloaddition reaction of azomethine ylides has been developed for the synthesis of pyrrolidine-fused tetracyclic compounds. This reaction efficiently and stereoselectively generates six bonds and seven chiral centers in a one-pot reaction process.

Graphical abstract: One-pot double [3 + 2] cycloaddition for diastereoselective synthesis of tetracyclic pyrrolidine compounds

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Article information

DOI
https://doi.org/10.1039/C2GC36066G
Article type
Communication
Submitted
11 Jul 2012
Accepted
31 Aug 2012
First published
04 Sep 2012

Green Chem., 2012,14, 3010-3012

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One-pot double [3 + 2] cycloaddition for diastereoselective synthesis of tetracyclic pyrrolidine compounds

Q. Lu, G. Song, J. P. Jasinski, A. C. Keeley and W. Zhang, Green Chem., 2012, 14, 3010 DOI: 10.1039/C2GC36066G

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