Issue 95, 2012
From the journal:

Chemical Communications

Medicinal gold compounds form tight adducts with the copper chaperone Atox-1: biological and pharmacological implications†

Chiara Gabbiani,a   Federica Scaletti,b   Lara Massai,b   Elena Michelucci,c   Maria A. Cinellud  and  Luigi Messori*b  

* Corresponding authors

a Department of Chemistry and Industrial Chemistry, via Risorgimento 35, 56126 Pisa, Italy

b Laboratory of ‘‘Metals in Medicine’’ (METMED), Department of Chemistry ‘‘Ugo Schiff’’, University of Florence, Via della Lastruccia 3, 50019 Sesto Fiorentino, Firenze, Italy
E-mail: luigi.messori@unifi.it
Fax: +39 055 4573385
Tel: +39 055 4573388

c Mass Spectrometry Centre (CISM), University of Florence, Via U. Schiff 6, 50019 Sesto Fiorentino, Firenze, Italy

d Department of Chemistry, University of Sassari, Via Vienna 2, 07100 Sassari, Italy

Abstract

Based on ESI-MS measurements, we show here that some representative cytotoxic gold(III) compounds produce stable adducts upon reaction with the copper chaperone Atox-1; notably, such adducts contain gold in the oxidation state +1. These findings are of interest to understand the intracellular metabolism of medicinal gold species and to develop new potent inhibitors of the copper trafficking system.

Graphical abstract: Medicinal gold compounds form tight adducts with the copper chaperone Atox-1: biological and pharmacological implications

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Article information

DOI
https://doi.org/10.1039/C2CC36610J
Article type
Communication
Submitted
11 Sep 2012
Accepted
15 Oct 2012
First published
16 Oct 2012

Chem. Commun., 2012,48, 11623-11625

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Medicinal gold compounds form tight adducts with the copper chaperone Atox-1: biological and pharmacological implications

C. Gabbiani, F. Scaletti, L. Massai, E. Michelucci, M. A. Cinellu and L. Messori, Chem. Commun., 2012, 48, 11623 DOI: 10.1039/C2CC36610J

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