Issue 69, 2012
From the journal:

Chemical Communications

A dual-signalling electrochemical DNA sensor based on target hybridization-induced change in DNA probe flexibility†

Weiwei Yangab  and  Rebecca Y Lai*a  

* Corresponding authors

a University of Nebraska-Lincoln, 651 Hamilton Hall, Lincoln, NE 68588-0304, USA
E-mail: rlai2@unl.edu
Fax: +1 402 472 9402
Tel: +1 402 472 5340

b School of Chemical Engineering and Technology, Harbin Institute of Technology, Harbin, Heilongjiang 150001, China
E-mail: wyang.chem@gmail.com

Abstract

We report a fully covalent, dual-signalling electrochemical DNA sensor that exploits competitive binding and target hybridization-induced change in probe flexibility for simple and robust detection of target DNA.

Graphical abstract: A dual-signalling electrochemical DNA sensor based on target hybridization-induced change in DNA probe flexibility

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Article information

DOI
https://doi.org/10.1039/C2CC34312F
Article type
Communication
Submitted
16 Jun 2012
Accepted
12 Jul 2012
First published
12 Jul 2012

Chem. Commun., 2012,48, 8703-8705

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A dual-signalling electrochemical DNA sensor based on target hybridization-induced change in DNA probe flexibility

W. Yang and R. Y. Lai, Chem. Commun., 2012, 48, 8703 DOI: 10.1039/C2CC34312F

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