A dual-targeting hybrid platinum(IV) prodrug for enhancing efficacy

Haihua Xiao; Lesan Yan; Yu Zhang; Ruogu Qi; Wenliang Li; Rui Wang; Shi Liu; Yubin Huang; Yuxin Li; Xiabin Jing

doi:10.1039/C2CC34297A

A dual-targeting hybrid platinum(iv) prodrug for enhancing efficacy†

Haihua Xiao,^ab Lesan Yan,^ab Yu Zhang,^c Ruogu Qi,^ab Wenliang Li,^ab Rui Wang,^ab Shi Liu,^ab Yubin Huang,^a Yuxin Li*^c and Xiabin Jing*^a

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* Corresponding authors

^a State Key Laboratory of Polymer Physics and Chemistry, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun 130022, People's Republic of China
E-mail: xbjing@ciac.jl.cn

^b Graduate School of Chinese Academy of Sciences, Beijing 100049, China

^c National Engineering Laboratory for Druggable Gene and Protein Screening, Northeast Normal University, Changchun 130024, People's Republic of China
E-mail: liyx486@nenu.edu.cn

Abstract

A multifunctional hybrid platinum(IV) prodrug, which consists of both the mitochondria-targeting drug DCA and the DNA-crosslinking drug cisplatin, was synthesized and tethered to a carrier polymer to further self-assemble into micelles for intracellular delivery.

Chemical Communications

A dual-targeting hybrid platinum(iv) prodrug for enhancing efficacy†

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A dual-targeting hybrid platinum(IV) prodrug for enhancing efficacy

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