Issue 53, 2012

Covalent attachment of antagonists to the α7 nicotinic acetylcholine receptor: synthesis and reactivity of substituted maleimides

Abstract

The 3-methylmaleimide congeners of the natural product methyllycaconitine (MLA) and an analogue covalently attach to functional cysteine mutants of the α7 nicotinic acetylcholine receptor (nAChR).

Graphical abstract: Covalent attachment of antagonists to the α7 nicotinic acetylcholine receptor: synthesis and reactivity of substituted maleimides

Supplementary files

Article information

Article type
Communication
Submitted
05 Apr 2012
Accepted
09 May 2012
First published
10 May 2012

Chem. Commun., 2012,48, 6699-6701

Covalent attachment of antagonists to the α7 nicotinic acetylcholine receptor: synthesis and reactivity of substituted maleimides

J. I. Ambrus, J. I. Halliday, N. Kanizaj, N. Absalom, K. Harpsøe, T. Balle, M. Chebib and M. D. McLeod, Chem. Commun., 2012, 48, 6699 DOI: 10.1039/C2CC32442C

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