Issue 37, 2012
From the journal:

Chemical Communications

Ugi reaction-assisted rapid assembly of affinity-based probes against potential proteintyrosine phosphatases†

Jingyan Ge,a   Xiamin Cheng,a   Lay Pheng Tanb  and  Shao Q. Yao*ab  

* Corresponding authors

a Department of Chemistry, National University of Singapore, 3 Science Drive 3, Singapore 117543, Singapore
E-mail: chmyaosq@nus.edu.sg
Fax: +65 67791691
Tel: +65 65162925

b Department of Biological Sciences, National University of Singapore, 3 Science Drive 3, Singapore 117543, Singapore
Fax: +65 67791691
Tel: +65 65162925

Abstract

The multi-component Ugi reaction has been employed to assemble a small library of affinity-based probes (AfBPs) that target potential protein tyrosine phosphatases. The probes showed good labelling of PTP1B and MptpB, and were subsequently used to label endogenous PTP1B in MCF-7 cell lysates.

Graphical abstract: Ugi reaction-assisted rapid assembly of affinity-based probes against potential protein tyrosine phosphatases

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Article information

DOI
https://doi.org/10.1039/C2CC31294H
Article type
Communication
Submitted
21 Feb 2012
Accepted
15 Mar 2012
First published
16 Mar 2012

Chem. Commun., 2012,48, 4453-4455

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Ugi reaction-assisted rapid assembly of affinity-based probes against potential protein tyrosine phosphatases

J. Ge, X. Cheng, L. P. Tan and S. Q. Yao, Chem. Commun., 2012, 48, 4453 DOI: 10.1039/C2CC31294H

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