Multi-walled carbon nanotubes modified glassy carbon electrode for sensitive determination of ketoconazole

Abstract

The electrochemical behavior of ketoconazole (KC) on a multi-walled carbon nanotubes (MWCNTs)-modified glassy carbon (GC) electrode was investigated in this work. The result indicated that MWCNTs remarkably promoted the electrochemical response of KC on the GC electrode. To achieve a sensitive voltammetric determination of KC, experimental conditions such as solution pH, amount of MWCNTs, accumulation time as well as scan rate were systematically studied and optimized. Under optimized conditions, the differential pulse voltammetric (DPV) response on the MWCNTs-modified electrode was proportional to the KC concentration in the range of 1.0 × 10⁻⁶–3.0 × 10⁻⁵ mol L⁻¹ with a detection limit of 4.4 × 10⁻⁷ mol L⁻¹. Based on this MWCNTs-modified electrode, KC in a pharmaceutical drug (Ketoconazole^®) was successfully determined without requirement of complicated sample pretreatment.